Table of Contents
Front Matter
Executive Summary
1 Introduction and Background
2 Approaches Used by Others and Existing Safety Frameworks
3 The Framework
4 Categories of Scientific Evidence--Human Information and Data
5 Categories of Scientific Evidence--Animal Data
6 Categories of Scientific Evidence--Information About Related
Substances
7 Categories of Scientific Evidence--In Vitro Data
8 Interactions
9 Vulnerable Groups and Prevalance of Use
10 Scientific Principles for Integrating and Evaluating the
Available Data
11 Applying the Framework: Case Studies Using the Prototype Safety
Monographs
12 Factors Influencing Use of the Safety Framework
13 Findings and Recommendations
Appendix A: Existing Frameworks or Systems for Evaluating the
Safety of Other Substances
Appendix B: Scope of Work and Comments to Initial July 2002
Framework
Appendix C: Plant Family Information
Appendix D: Chaparral: Prototype Monograph Summary
Appendix E: Glucosamine: Prototype Monograph Summary
Appendix F: Melatonin: Prototype Monograph Summary
Appendix G: Chromium Picolinate: Prototype Monograph Summary
Appendix H: Saw Palmetto: Prototype Monograph Summary
Appendix I: Shark Cartilage: Prototype Monograph Summary
Appendix J: Prototype Focused Monograph: Review of Liver-Related
Risks for Chaparral
Appendix K: Protoype Focused Monograph: Review of Anti-Androgenic
Risks of Saw Palmetto Ingestion by Women
Appendix L: Acknowledgements
Appendix M: Biographical Sketches of Commitee Members
Index
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