Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.


Table of Contents


Front Matter
Summary
1 Introduction
2 The Impact of Social and Cultural Environment on Health
3 Genetics and Health
4 Genetic, Environmental, and Personality Determinants of Health
Risk Behaviors
5 Sex/Gender, Race/Ethnicity, and Health
6 Embedded Relationships Among Social, Behavioral, and Genetic
Factors
7 Animal Models
8 Study Design and Analysis for Assessment of Interactions
9 Infrastructure
10 Ethical, Legal, and Social Implications
11 Conclusion
Appendix A Methodology: Data Collection and Analysis
Appendix B Recommendation from the National Academy of Sciences
Report, Facilitating Interdisciplinary Research
Appendix C Social Environmental and Genetic Influences on Obesity
and Obesity-Promoting Behaviors
Appendix D The Interaction of Social, Behavioral, and Genetic
Factors in Sickle-Cell Disease
Appendix E Modern Epidemiologic Approaches to Interaction:
Applications to the Study of Genetic Interactions
Appendix F Acronyms
Appendix G Biographical Sketches
Index