The second edition of these Guidelines provides simple and straightforward treatment recommendations based on sound evidence that can be applied even in severely resource-constrained settings. The number of antimalarial drug trials published has continued to increase over the years, so the Guidelines have a firmer evidence base than previous treatment recommendations.
Since the release of the first edition, the WHO standard methods for guidelines development has evolved and this second edition was developed in accordance with the updated WHO standards methods for guidelines development. This methodology incorporates a transparent link between research evidence and recommendations. The GRADE system, which has been incorporated into this update, is a uniform approach being widely adopted globally.
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