Inspired by a real-life behavioral scientist, Lie To Me tells the tale of a deception expert who helps uncover the truth for the FBI, local police, law firms, corporations, and individuals.

Dr. Cal Lightman and his team are effectively human polygraph machines, and no truth can be concealed from them. The Lightman Group is headed by Dr. Cal Lightman and his partner Dr. Gillian Foster who is a gifted psychologist. She brings balance to the partnership by thinking about the overall picture while Lightman focuses on the details. Together they make an invincible team with insight into human behavior. Will Loker is the lead researcher, who believes in radical honesty. He often gets in trouble for saying what he thinks. Ria Torres is one of the few "naturals" in the field of deception detection. She has an untapped ability to read people that makes her a force to be reckoned with the right training.