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Actin Polymerization in Apicomplexan

Actin Polymerization in Apicomplexan

A Structural, Functional and Evolutionary Analysis

by Avinash Kale
Hardback
Publication Date: 01/12/2019
  $227.95
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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

ISBN:
9789811374494
9789811374494
Category:
Proteins
Format:
Hardback
Publication Date:
01-12-2019
Language:
English
Publisher:
Springer
Country of origin:
United States
Dimensions (mm):
235x155mm
Weight:
0.35kg

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