This Special Issue book covers a wide scope in the research field of 3D-printing, including: the use of 3D printing in system design; AM with binding jetting; powder manufacturing technologies in 3D printing; fatigue performance of additively manufactured metals, such as the Ti-6Al-4V alloy; 3D-printing methods with metallic powder and a laser-based 3D printer; 3D-printed custom-made implants; laser-directed energy deposition (LDED) process of TiC-TMC coatings; Wire Arc Additive Manufacturing; cranial implant fabrication without supports in electron beam melting (EBM) additive manufacturing; the influence of material properties and characteristics in laser powder bed fusion; Design For Additive Manufacturing (DFAM); porosity evaluation of additively manufactured parts; fabrication of coatings by laser additive manufacturing; laser powder bed fusion additive manufacturing; plasma metal deposition (PMD); as-metal-arc (GMA) additive manufacturing process; and spreading process maps for powder-bed additive manufacturing derived from physics model-based machine learning.