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Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

by Domenico Ribatti
Hardback
Publication Date: 07/01/2014
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It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
ISBN:
9789401780346
9789401780346
Category:
Oncology
Format:
Hardback
Publication Date:
07-01-2014
Language:
English
Publisher:
Springer
Country of origin:
Netherlands
Pages:
114
Dimensions (mm):
235x155x13mm
Weight:
3.43kg

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