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Bioisosteres in Medicinal Chemistry

Bioisosteres in Medicinal Chemistry

by Nathan Brown
Hardback
Publication Date: 22/08/2012

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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
ISBN:
9783527330157
9783527330157
Category:
Pharmacology
Format:
Hardback
Publication Date:
22-08-2012
Language:
English
Publisher:
Wiley-VCH Verlag GmbH
Country of origin:
Germany
Pages:
256
Dimensions (mm):
246x174x16mm
Weight:
0.63kg

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