This book offers a unique perspective on the colonial roots of modern science, technology, and medicine (STM) in South Asia. The book questions the deconstruction of imperial visions and definitions of science and modernity in South Asia. It presents an in-depth analysis of the contested relationship between science, modernity, and colonialism. It explores how new research can contribute to the diversification of perspectives in the history and sociology of modern South Asian studies. The chapters in the book delve into various aspects of STM in South Asia. It covers diverse topics, including the social, cultural, and pedagogic context of early modern Bengal, the popularization of science in colonial Punjab, the Hindi science periodical Vigyan, and the emergence of the Indian science community. The book also examines the intersection of indigenous medical practices, ayurveda, and medical revivalism and highlights peripheral creativity in science. The contributors engage with the existing historiography to raise new questions concerning the global circulations of scientific knowledge from the perspective of South Asia and the regional appropriation of the same. It connects the history of science and modernity with South Asia's socio-economic and cultural background. It offers valuable insights into the decolonization of STM. It greatly interests scholars and students of modern South Asian history, sociology, social anthropology, and Science, Technology and Society Studies (STS).