The Covid-19 pandemic has ushered in an era of unprecedented change, fundamentally reshaping the fabric of our global society. This book, drawing from an international congress of scholars in Medical Humanities and Media Studies, explores the profound impact of the pandemic on Ibero-America, shedding light on the intricate web of historical antecedents, societal structures, and contemporary consequences. It delves into the pandemic's role as a crucible for social inequalities, revealing the unique challenges faced in Ibero-America, such as informal labor markets and healthcare access disparities. From politics to culture, this collection of essays examines the multifaceted responses to the pandemic, probing the intricate dance between state control, economic dynamics, and cultural creativity. It also offers a comparative lens on past health crises and their resonance in literature and media.