Gwendolyn "Gwen" Dylan is a 20-something gravedigger in an eco-friendly cemetery. Once a month she must eat a human brain to keep from losing her memories, but in the process she becomes consumed with the thoughts and personality of the dead person - until she eats her next brain. She sets out to fulfill the dead person's last request, solve a crime or right a wrong.

In uVAMPIRE, Gwen dines on the grey matter of a person who knew her as a child - and things quickly get complicated. Meanwhile, ghost-girl Ellie learns a few tricks from Amon the mummy; Spot the were-terrier goes to the comics shop and meets someone from Gwen's past, the mad scientist Galatea engages in a bit of grave-robbing; and the monster-hunters tackle the town's vampire problem once and for all.