The proceedings volume provides an account of the pandemic-inspired policy changes in leadership, entrepreneurship, and sustainable development. The volume is a collection of papers presented at the 2022 International Leadership Conference hosted by the Prague Institute for Qualification Enhancement (PRIZK), Czech Republic. The focus of the conference was to outline positive changes for leadership in business and economics based on the lessons learned during the pandemic. The enclosed selection of papers describe the digital surge in business, economics, and education, as well as the development of frontier technologies caused by the COVID-19 lockdown periods. They also provide new insights into the concepts of leadership, entrepreneurship, and sustainable development post the COVID-19 pandemic. Finally, the papers define the new place and role of leadership within the context of global initiatives in sustainability such as the European Union's Green Deal and the United Nations' Sustainable Development Goals (SGDs).