AD 2100: The world has been devastated by a manmade plague. Young Daisy Ogami is infected but unaffected--naturally immune. In her blood can be found a cure that will save humanity. But the remaining world powers are concerned less with preserving humanity and more with being the first nation to return to power. Unfortunately for them, Daisy has a protector . . . a loyal android named Itto.

In a violent reimagining of the classic assassin-and-child story of Kazuo Koike and Goseki Kojima's Lone Wolf and Cub, Itto and Daisy set out across the Plague Lands, looking for a way to save the world while pursued by plague victims, ruthless mercenaries, and the armored soldiers of dying nations. Pity those who catch up with them . . .

Collects Lone Wolf 2100: Chase the Setting Sun 1-4.