In the oral environment, restorative and prosthetic materials and appliances are exposed to chemical, thermal and mechanical challenges. The mechanical properties of a material define how it responds to the application of a physical force. Recent advances in nanotechnology and 3D printing have rapidly spread, and manufacturers continuously develop new materials and solutions to provide high-quality dental care, with particular attention being paid to long-term follow-up. Restorative dentistry, prosthodontics, oral surgery, implants, periodontology and orthodontics are all involved in this continuing evolution. This Special Issue focuses on all the recent technology that can enhance the mechanical properties of materials used in all of the different branches of dentistry.