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Necrotizing Enterocolitis

Necrotizing Enterocolitis

Insights Into the Pathogenesis of This Challenging Disease

by Michael Caplan
Paperback
Publication Date: 30/12/2013
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Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathogenesis is poorly understood, and therefore there are no specific preventive or treatment strategies that have been clearly effective. Recent studies have suggested that the pathophysiology of necrotizing enterocolitis includes alterations in the inflammatory response leading to dysregulated pro-inflammatory signaling in premature infants, as well as abnormal intestinal bacterial colonization patterns that can activate these inflammatory pathways, and these factors are discussed in depth in the following chapters. While human milk feedings are currently the standard of care for the prevention of this challenging condition, new approaches will be described based on sound evidence that might have a significant impact for premature infants throughout the world.
ISBN:
9781615045907
9781615045907
Category:
Physiology
Format:
Paperback
Publication Date:
30-12-2013
Publisher:
Morgan & Claypool Publishers
Country of origin:
United States
Pages:
94
Dimensions (mm):
235x187x5mm
Weight:
0.17kg

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