Alex de Campi is well known for her 2005 mini-series Smoke (published by IDW Publishing, art by Igor Kordey), which was nominated for the Eisner Award for Best Limited Series, and her 2006 manga series Kat & Mouse (published by Tokyopop, art by Federica Manfredi).

De Campi's work falls outside the superhero genre, with Smoke being a political thriller, and Kat & Mouse detailing the adventures of two mystery-solving high school students (a "CSI for tweens"); she has published work for children (e.g. Agent Boo) and for the European market (e.g. her French language sci-noir series Messiah Complex).