Free Shipping on Order Over $60
AfterPay Available
Processing of VEGF-C and -D by the Proprotein Convertases

Processing of VEGF-C and -D by the Proprotein Convertases

Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis

by Geraldine Siegfried and Majid Khatib
Paperback
Publication Date: 30/11/2013
RRP  $86.90 $84.25
or 4 easy payments of $21.06 with
afterpay
This item qualifies for FREE delivery
The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -D, and placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-1, -2, and/or -3. In addition to their requirements in the initiation, development, and maintenance of blood and lymphatic vasculature, VEGFs and VEGFRs are upregulated during neoplasia and are involved in the remodeling of tumoral blood and lymphatic vasculature. By activating VEGFR-1 and VEGFR-2, both expressed on blood endothelial cells, VEGF-A promotes the formation of new tumoral blood vessels and thereby accelerates tumor growth. In contrast, upregulation of VEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for VEGFR-2, induces the formation of tumor-associated lymphatic vessels and thus promotes the passive metastatic dissemination of tumor cells to regional lymph nodes. Of the VEGF family members, only VEGF-C and -D were found to be proteolytically processed by Furin-like enzymes. This processing controls the selective activation of VEGFR-2 and -3 signaling during tumor angiogenesis and lymphangiogenesis. Here, we provide an overview of angiogenesis processes and discuss the importance of VEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation of VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis, lymphangiogenesis, and tumorigenesis.
ISBN:
9781615046102
9781615046102
Category:
Biochemistry
Format:
Paperback
Publication Date:
30-11-2013
Publisher:
Morgan & Claypool Publishers
Country of origin:
United States
Pages:
66
Dimensions (mm):
235x187x4mm
Weight:
0.13kg

This title is in stock with our Australian supplier and arrives at our Sydney warehouse within 7-10 working days of you placing an order.

Once received into our warehouse we will despatch it to you with a Shipping Notification which includes online tracking.

Please check the estimated delivery times below for your region, for after your order is despatched from our warehouse:

ACT Metro 2 working days

NSW Metro 2 working days 

NSW Rural 2-3 working days

NSW Remote 2-5 working days

NT Metro 3-6 working days

NT Remote 4-10 working days

QLD Metro 2-4 working days

QLD Rural 2-5 working days

QLD Remote 2-7 working days

SA Metro 2-5 working days

SA Rural 3-6 working days

SA Remote 3-7 working days

TAS Metro 3-6 working days

TAS Rural 3-6 working days

VIC Metro 2-3 working days

VIC Rural 2-4 working days

VIC Remote 2-5 working days

WA Metro 3-6 working days

WA Rural 4-8 working days

WA Remote 4-12 working days

Customer Reviews

Be the first to review Processing of VEGF-C and -D by the Proprotein Convertases.