This manual will contribute to addressing the challenge of antimicrobial resistance (AMR) by promoting the prevention of infections and the prudent use of antibiotics in the pig and poultry sectors, the livestock sectors that generally have the highest use of antibiotics. It should be regarded as a practical complement to national governance and regulatory measures. Antimicrobials are widely used in both humans and livestock and have greatly contributed to better human and animal health. However, these benefits are being threatened by the global emergence of AMR. One way to mitigate the emergence of AMR is to reduce the overall use of antibiotics by combining prudent and medically rational use with other disease preventive measures. The manual will assist pharmacists, veterinarians, other animal health workers, farm owners and their staff in using antibiotics in a prudent and medically efficient way without loss in productivity. Many of the principles and practices described here are universal and may also be applied elsewhere.