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Resistance of Cancer Cells to CTL-Mediated Immunotherapy

Resistance of Cancer Cells to CTL-Mediated Immunotherapy

by Benjamin Bonavida and Salem Chouaib
Hardback
Publication Date: 31/05/2015
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This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.
ISBN:
9783319178066
9783319178066
Category:
Molecular biology
Format:
Hardback
Publication Date:
31-05-2015
Language:
English
Publisher:
Springer
Country of origin:
United States
Dimensions (mm):
235x155mm
Weight:
7.54kg

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