Free shipping on orders over $99
Scaffold Hopping in Medicinal Chemistry

Scaffold Hopping in Medicinal Chemistry

by Nathan Brown
Hardback
Publication Date: 04/12/2013

Share This Book:

 
$284.95
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.

The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry.

While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
ISBN:
9783527333646
9783527333646
Category:
Chemistry
Format:
Hardback
Publication Date:
04-12-2013
Language:
English
Publisher:
Wiley-VCH Verlag GmbH
Country of origin:
Germany
Pages:
328
Dimensions (mm):
249x177x23mm
Weight:
0.84kg

Click 'Notify Me' to get an email alert when this item becomes available

Reviews

Be the first to review Scaffold Hopping in Medicinal Chemistry.