This book contributes to the multidisciplinary debate about social-ecological systems (SES) within the perspective of rethinking the nature of interaction between these systems, especially in the Anthropocene Era. Most chapters either deliberate on risk dynamics threatening current SES or stimulate thought processes to manage such risks and related negative implications. After analyzing the main drivers of SES vulnerability, the book highlights the shifts to be made to enhance the sustainability and resilience of these systems, mainly the integration and restructuring of governance frameworks, the reorganization of production and consumption systems far from conventional models based on consumerism, the elaboration of mitigation, adaptation, and SDGs implementation measures from a co-benefit perspective, and the consideration of appropriate approaches and paradigms while elaborating and implementing response mechanisms. This volume is relevant to researchers/experts, students, practitioners, and decision-makers from different scales and spheres.