This study examines the reception of Cleopatra from the beginning of the 20th century to the present day as it has been reflected in popular culture in the United States of America. Daugherty provides a broad overview of the influence of the Egyptian queen by looking at her presence in film, novels, comics, cartoons, TV shows, music, advertising and toys. The aim of the book is to show the different ways in which the figure of Cleopatra was able to reach a large and non-elite audience.

Furthermore, Daugherty makes a study of the reception of Cleopatra during her own lifetime. He begins by looking at her portrayal in the vicious propaganda campaign waged by Octavian against his rival Marc Antony. The consequence was that Cleopatra was left with a tarnished reputation after the civil war. Daugherty's examination of both the historical and contemporary reception of Cleopatra shows the enduring legacy of one of history's most remarkable queens.