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Thymic Development and Selection of T Lymphocytes

Thymic Development and Selection of T Lymphocytes

by Yousuke Takahama and Thomas Boehm
Hardback
Publication Date: 07/11/2013
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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
ISBN:
9783642402517
9783642402517
Category:
Physiology
Format:
Hardback
Publication Date:
07-11-2013
Language:
English
Publisher:
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Country of origin:
Germany
Pages:
132
Dimensions (mm):
235x155x15mm
Weight:
3.38kg

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