This issue of Cardiology Clinics, curated by Drs. Mark A. Creager and Stanislav Henkin, will explore topics related to Vascular Medicine. This issue is one of four selected each year by the series editorial board: Jamil A. Aboulhosn, David M. Shavelle, Terrence D. Welch, and Audrey H. Wu. Topics in this volume include, but are not limited to: Medical management of peripheral artery disease, Revascularization strategies for acute and chronic limb ischemia, Acute aortic syndromes, Thoracic aortic aneurysms, Abdominal aortic and visceral artery aneurysms, Renal and mesenteric artery disease, Extracranial carotid artery disease, Venous thromboembolism, Varicose veins and chronic venous insufficiency, Raynaud phenomenon and other vasospastic disorders.