This volume presents research and expository papers highlighting the vibrant and fascinating study of irregularities in the distribution of primes. Written by an international group of experts, contributions present a self-contained yet unified exploration of a rapidly progressing area. Emphasis is given to the research inspired by Maier’s matrix method, which established a newfound understanding of the distribution of primes. Additionally, the book provides an historical overview of a large body of research in analytic number theory and approximation theory. The papers published within are intended as reference tools for graduate students and researchers in mathematics.