The International Conference on Health Care Systems Engineering (HCSE) provided a timely opportunity to discuss statistical analysis and operations management issues in health care delivery systems. The conference took place in Milan between May 22nd and 24th, 2013. Scientists and practitioners discussed new ideas, methods and technologies for improving the operation of health care organizations. The event and this resulting volume emphasize research in the field of health care systems engineering developed in close collaboration with clinicians. Topics applicable to researchers and practitioners include: hospital drug logistics, operating theatres, modelling and simulation in patient care and healthcare organizations, home care services.