Matt (Jason Sudeikis), is a recently divorced, struggling music executive on a downward spiral, when his father's nurse Zooey (Elizabeth Olsen) shows up unexpectedly. His estranged father Ben (Ed Harris)--a celebrated photographer--has been diagnosed with terminal cancer.

After finding four rolls of Kodachrome film, Ben's dying wish is for Matt to drive him cross-country to process the film at Dwayne's--the last place in the world that still develops Kodachrome--before Kodak shuts down their lab for good. Hauling half a lifetime of baggage and resentment, Matt, Ben and Zooey set out for the long, redemptive road trip from New York to Kansas.