The most important event in the history of mankind is happening right now. In the blink of an eye, the Rapture strikes the world. Millions of people disappear without a trace. All that remains are their clothes and belongings and in an instant, terror and chaos spread around the world. The vanishings cause unmanned vehicles to crash and burn. Planes fall from the sky. Emergency forces everywhere are devastated. Gridlock, riots and looting overrun the cities. There is no one to help or provide answers.

In a moment, the entire planet is plunged into darkness. The Steele family is caught on the razor's edge of that darkness. Ray Steele (Nicolas Cage), an airline pilot, struggles to calm and ultimately to save the lives of the passengers that remain on his flight, as the world below loses its ability to help his plane and any other to safety. Running out of fuel, his equipment failing, his crew escalating into panic, Ray must guide the plane with the help of GWN reporter, Cameron "Buck" Williams (Chad Michael Murray) who takes over the role of co-pilot in the face of the crisis.

On the ground, Ray's daughter Chloe Steele (Cassi Thomson) struggles to find her young brother and mother, both of whom may have disappeared in the Biblical event. Forcing herself through the chaos, Chloe must navigate a world filled with terror and despair.