Andy is now 17 and ready to head off to college, leaving Woody, Buzz, Jessie, and the rest of the toy-box gang to ponder their uncertain futures. When the toys are accidentally donated to the Sunnyside Daycare center they're initially overjoyed to once again be played with, but their enthusiasm quickly gives way to horror as they discover the true nature of the establishment under the rule of the deceptively welcoming "Lotso" Bear. Now, all of the toys must band together in one final, crazy scheme to escape their confines and return home to Andy.