On the verge of qualifying for the surgery that will complete her transformation from Stanley to Sabrina, Bree (Felicity Huffman) is given one last hurdle by her therapist - she must confront Toby (Kevin Zegers), a previously unknown son from a once-only heterosexual encounter over twenty years ago, currently in police custody.
When they meet, Toby believes Bree to be a Christian missionary and has no clue that she's a he, or that he's her son. Together they head on a road trip from New York to LA, where Bree is to have her operation and Toby will pursue stardom. What transpires between them is often hilarious and moving as two lost souls discover their connection. What ensues is a compressed course in parenthood for Bree, a lesson in trust for Toby and a truckload of fun for the viewer.
As each tries to maintain their facade, Bree and Toby find themselves travelling across the heartland of a continent on a charming, tender and often hilarious journey.