After leaving the force, Elijah Kane (Steven Seagal) falls back into his special forces past, re-emerging from the ashes of his destroyed Special Investigations Unit to once again work for the government. Aware of his skill as a long-range sniper, Kane is recruited by Marcus Mitchell of the CIA to come back as an operative. In return, Marcus promises that the CIA will provide information to Kane about who put out the hit on his SIU team. Kane is given a long-term 'off-the-grid' mission to take out a high level target that the CIA cannot go after in the 'traditional' way. Marcus feeds Kane Intel that leads him into the target's 'circle' with a goal of getting Kane close enough to take a kill shot from a distance. Only then will the identity of the target be revealed to the team. For this operation, Kane recruits three agents to form a new team of operatives. All three are trained by Kane and ultimately driven (like Kane) by not just business, but also for personal reasons.

In One Shot, One Life, Kane and his team have removed The Ghost's support systems and Kane manoeuvres to get a shot at the man responsible for the attack on his precinct - but the FBI has taken notice of Kane's activities and they want him stopped. Kane's team struggles to get him close enough to take that shot...