Mary-Frances O'Connor, PhD is an associate professor of psychology at the University of Arizona, where she directs the Grief, Loss and Social Stress (GLASS) Lab, which investigates the effects of grief on the brain and the body. O'Connor received her BA in psychology from Northwestern University in 1996, and went on to earn a PhD in clinical psychology from the University of Arizona in 2004.

She completed clinical training at the formerly named UCLA Neuropsychiatric Institute and Hospital and has worked in clinical settings from Arizona State Prison to the Revlon UCLA Breast Center. Soon after, she completed a post-doctoral fellowship in psychoneuroimmunology at the UCLA Semel Institute for Neuroscience and Human Behavior. She then joined the faculty at UCLA before moving to the psychology department at the University of Arizona in 2012. She lives in Tucson, Arizona.