The stirring saga of one famous cane toad continues ... Limpy is tired of seeing his relatives run over. When he hears of a place where cane toads and humans live in harmony, he is determined to go there and find out the secret himself. Limpy finds a migratory bird who agrees to carry him to South America in his claws, he plans to take Goliath along to stop him declaring war on every human he comes across. Then, to his horror, he discovers that his little sister Charm has learned of his plan and has gone instead. Limpy and Goliath are determined to catch up with Charm, after an eventful trip via bird claws and the underside of a seat on a plane, they end up in the Amazon. While searching for Charm, Limpy and Goliath discover that the jungle is a violent place, Limpy comes into contact with his doppelganger - a toad whose had allowed the squashing of his face and leg by humans to turn him nasty. When Limpy finds evidence (so he thinks) that Charm has been killed by a bulldozer, he considers siding with Flatface in a war against the humans, but his customary good sense and kind nature reasserts itself. He then discovers that Charm is most probably not dead, and, on the advice of the Amazonian cane toads, seeks out the wise man who can see everything. The wise man not only helps him locate Charm, but gives him the secret of living in harmony with humans.