When neuroscientist Edward Armstrong begins dating Kimberly Stewart, a descendant of a woman who was hanged as a witch at the time of the Salem witch trials, he takes advantage of the opportunity to delve into a pet theory: that the "devil" in Salem in 1692 had been a hallucinogenic drug inadvertently consumed with mold-tainted grain. In an attempt to prove his theory, Edward grows the mold he believes responsible with samples from the Stewart estate. In a brilliant designer-drug transformation, the poison becomes Ultra, the next generation of antidepressants with truly startling therapeutic capabilties.

But who can be sure the drug is safe for consumers? Who defines the boundaries of "normal" human behavior? And if the drug's side effects are proven to be dangerous--even terrifying--how far will the medical community go to alter their standards of acceptable risk?