In 2002, the world changes forever. Every man, every boy, every mammal with a Y chromosome everywhere on Earth suddenly collapses and dies. The gears of society grind to a halt. In the aftermath, a world of women is left to piece together the wreckage and keep civilization from collapsing completely. The "gendercide," however, is not absolute--a single man named Yorick Brown and his pet monkey are spared.

So begins an extraordinary journey, as the world's two remaining males set out to solve the mystery of the sex-specific plague and preserve the future of mankind. But how can one man save an entire species when his heart belongs to only one woman--and she's on the other side of the globe?

This final volume collects issues #41-60 of the groundbreaking VERTIGO series and includes the complete script by Vaughan and pencilled pages by guest artist Goran Sudžuka for issue #53.