Technical Innovation in American History surveys the history of technology, documenting the chronological and thematic connections between specific inventions, technological systems, individuals, and events that have contributed to the history of science and technology in the United States. Covering eras from colonial times to the present day in three chronological volumes, the entries include innovations in fields such as architecture, civil engineering, transportation, energy, mining and oil industries, chemical industries, electronics, computer and information technology, communications (television, radio, and print), agriculture and food technology, and military technology.

The A-Z entries address key individuals, events, organizations, and legislation related to themes such as industry, consumer and medical technology, military technology, computer technology, and space science, among others, enabling readers to understand how specific inventions, technological systems, individuals, and events influenced the history, cultural development, and even self-identity of the United States and its people. The information also spotlights how American culture, the U.S. government, and American society have specifically influenced technological development.