While the efficacy of cognitive therapy for depression is well established, every clinician is likely to encounter patients who do not respond to standard protocols. In this highly practical volume, leading authorities provide a unified set of clinical guidelines for conceptualizing, assessing, and treating challenging presentations of depression. Presented are detailed, flexible strategies for addressing severe, chronic, partially remitted, or recurrent depression, as well as psychiatric comorbidities, medical conditions, and family problems that may complicate treatment. The book also offers essential knowledge and tools for delivering competent care to specific populations of depressed patients: ethnic minorities; lesbian, gay, and bisexual people; adolescents; and older adults.