This two-volume set LNCS 6691 and 6692 constitutes the refereed proceedings of the 11th International Work-Conference on Artificial Neural Networks, IWANN 2011, held in Torremolinos-Malaga, Spain, in June 2011. The 154 revised papers were carefully reviewed and selected from 202 submissions for presentation in two volumes. The first volume includes 69 papers organized in topical sections on mathematical and theoretical methods in computational intelligence; learning and adaptation; bio-inspired systems and neuro-engineering; hybrid intelligent systems; applications of computational intelligence; new applications of brain-computer interfaces; optimization algorithms in graphic processing units; computing languages with bio-inspired devices and multi-agent systems; computational intelligence in multimedia processing; and biologically plausible spiking neural processing.