The International Conference on Systems Science 2013 (ICSS 2013) was the 18th event of the series of international scientific conferences for researchers and practitioners in the fields of systems science and systems engineering. The conference took place in Wroclaw, Poland during September 10-12, 2013 and was organized by Wroclaw University of Technology and co-organized by: Committee of Automatics and Robotics of Polish Academy of Sciences, Committee of Computer Science of Polish Academy of Sciences and Polish Section of IEEE. The papers included in the proceedings cover the following topics: Control Theory, Databases and Data Mining, Image and Signal Processing, Machine Learning, Modeling and Simulation, Operational Research, Service Science, Time series and System Identification. The accepted and presented papers highlight new trends and challenges in systems science and systems engineering.