To ensure that efforts to improve our biodefensive capabilities continue in an efficient manner, this volume presents a thorough review of pertinent research, encouraging researchers to leverage relevant results, rather than duplicate them. With contributions from those who have developed the animal models presented, this book examines bacterial, viral, and toxic agents considered to pose the greatest threat. Each section on a specific agent provides background, followed by a description of those animal models employed, and a discussion of how the findings translate to human impact. New chapters include Brucellosis, Melioidosis, Rickettsials (R. prowazekii and R. rickettsii), and Abrin toxin. New guidance provided by the FDA on the implementation of the Animal Efficacy Rule are included.