This book presents the best-selected papers presented at the International Conference on Data Science, Computation and Security (IDSCS-2021), organized by the Department of Data Science, CHRIST (Deemed to be University), Pune Lavasa Campus, India, during April 16-17, 2021. The proceeding is targeting the current research works in the areas of data science, data security, data analytics, artificial intelligence, machine learning, computer vision, algorithms design, computer networking, data mining, big data, text mining, knowledge representation, soft computing, and cloud computing.