This volume represents a collection of manuscripts dealing with the roles and actions of lipid mediators and their impact on human physiology and disease pathogenesis. In particular these contributions focus on cancer, inflammation and cardiovascular disease. The most recent advances in the formation and actions of lipid mediators is discussed at the molecular and cellular level. The synthesis of novel inhibitors is discussed relevant to their potential impact on cancer and inflammatory disease therapy. In addition to the "classical" lipid mediators, this volume contains presentations of exciting new developments in anandamides, nitric oxide and isoeicosanoids. The data and concepts presented in this volume should be of interest to both clinicians and basic researchers in the fields of cancer and inflammation.