This book provides a comprehensive introduction to high transverse momentum reactions at hadron (proton-proton or proton-antiproton) colliders. It begins by introducing the Standard Model of high energy physics and describes the specialized detectors used. It then gives a general treatment of the reactions to be studied and summarizes the state of the art in hadron collider physics, defined by Tevatron results. The experimental program at the detectors being built for the Large Hadron Collider at CERN is described, with details of the search program and the general strategy to find the postulated Higgs particle. Speculations of physics beyond the Standard Model are also discussed. This book is suitable for graduate students and researchers in high energy physics. It incorporates a shareware program that enables the reader to reproduce many of the examples and exercises given in the text, and go beyond the scope of text into open-ended study.