This book focuses on novel design and systems engineering approaches, including theories and best practices, for promoting a better integration of people and engineering systems. It covers a range of hot topics related to: development of human-centered systems; interface design and human-computer interaction; usability and user experience; emergent properties of human behavior; innovative materials in manufacturing, biomechanics, and sports medicine, safety engineering and systems complexity business analytics, design and technology and many more. The book, which gathers selected papers presented at the 2nd International Conference on Human Systems Engineering and Design: Future Trends and Applications (IHSED 2019), held on September 16-18, 2019, at Universitat der Bundeswehr Munchen, Munich, Germany, provides researchers, practitioners and program managers with a snapshot of the state-of-the-art and current challenges in the field of human systems engineering and design.