Chapter 1. CADD: Some success stories from Sanjeevini and the way forward.- Chapter 2. Virtual Screening: practical application of docking, consensus scoring and rescoring using binding free energy.- Chapter 3. Aspects Of Protein Structure, Function And Dynamics In Rational Drug Designing.- Chapter 4. Role of advanced computing in the drug discovery process.- Chapter 5. Protein structure, dynamics and assembly: Implications for drug discovery.- Chapter 6. Recent trends in computer-aided drug design.- Chapter 7. Predicting Protein Folding and Protein Stability by Molecular Dynamics Simulations for Computational Drug Discovery.- Chapter 8. Magnitude and advancements of CADD in identifying therapeutic intervention against Flaviviruses.- Chapter 9. Elucidating protein-ligand interactions using high throughput biophysical techniques.- Chapter 10. In silico approach in drug design and drug discovery: An update.- Chapter 11. Biological Implications of Polyethylene Glycoland PEGylation: Therapautic Approaches Based on Biophysical Studies and Protein Structure-Based Drug Design Tools.- Chapter 12. Molecular Dynamics Simulation in Drug Discovery: Opportunities and Challenges.- Chapter 13. Theoretical characterization of intrinsically disordered proteins and relevant forcefields for them.