A guide to reforming science education to produce science learners who can guide their own inquiry and make sense of science for personal and professional goals throughout their lives. Built on over 25 years of research on inquiry instruction, it offers teachers, professional development leaders, curriculum designers, cognitive researchers, technologists, policy-makers, science educators and natural scientists the opportunity to work together to convert students into lifelong science learners - one inquiry project at a time. At the heart of the text are its methodology - design-based research studies - and its approach - leveraging technology. Representing the authors' research on mutually supportive combinations of inquiry and technology that extend throughout the complex educational system and sustain new practices, this volume advocates leveraging inquiry and technology to reform the full spectrum of science education activities - including instruction, curriculum, policy, professional development, and assessment.