As a child, Smith was drawn to Charles Schulz's Peanuts, Carl Barks's Donald Duck, and Walt Kelly's Pogo, and he began the daily practice of drawing his own stories. After writing his regular strip Thorn for The Ohio State University's student paper, Smith worked in animation before creating, writing, and illustrating his runaway success, Bone. A comedic fantasy epic, Bone focuses on the Bone cousins, white, bald cartoon characters run out of their hometown, lost in a distant, mysterious valley. The self-published Series ran from 1991 to 2004 and won numerous awards, including ten Eisner Awards.

This career-spanning collection of interviews, ranging from 1999 to 2017, enables readers to follow along with Smith's development as an independent creator, writer, and illustrator.