The book addresses the relationship between knowledge, complexity and innovation systems. It integrates research findings from a broad area including economics, business studies, management studies, geography, mathematics and science & technology contributions from a wide range group of international experts. In particular, it offers insights about knowledge creation and spillovers, innovation and learning systems, innovation diffusion processes and innovation policies.The contributions provide an excellent coverage of current conceptual and theoretical developments and valuable insights from both empirical and conceptual work. The reader gets an overview about the state of the art of the role of innovation systems and knowledge creation and diffusion in geographical space.