This multi-author volume brings together a wide range of reviews on different aspects of our knowledge of drug-resistance mechanisms. Particular attention is paid to mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularization of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book should be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.