Given his name because radical surgery has reduced him to preternatural thinness, Whispr is a thug. In a dark alley in Savannah, Whispr and his partner in crime, Jiminy Cricket, murder what they take to be a random tourist in order to steal his artificial hand. But the victim is also carrying an unusual silver thread, which Whispr and Jiminy grab as well.

Chance later deposits a wounded Whispr at the clinic of Dr. Ingrid Seastrom. Powerful forces have been searching for Whispr since he acquired the mysterious thread, and Jiminy has vanished. All Whispr wants to do is sell the thread, and when he offers to split the profits with Ingrid, she makes an astonishing discovery. So begins the formidable partnership between the Harvard-educated physician and the street-smart thief--as long as they can elude the enhanced assassins that are tracking them.